The Effects of College Students’ Dual Use of Electronic Cigarette and Conventional Cigarette on Depression

Purpose@#This study was conducted to find out the association between dual-use of the electronic cigarette (EC) and conventional cigarette (CC) and depression among undergraduate students. Methods: The participants of this study were 225 undergraduate students who were attending two universities located in Ulsan metropolitan city. Descriptive statistics and multiple regression were conducted to analyze the data. @*Results@#Nicotine dependence and depression were significantly higher in the dual-use group than in the single-use group. Dual-use of the EC and CC was significantly associated with depression among undergraduate students. In addition, quality of sleep was significantly associated with depression among undergraduate students. @*Conclusion@#In order to prevent depression among undergraduate students, it is necessary to improve the awareness of the danger of dual use of the EC and CC.

The Relationship between Parenting Stress and Health Promotion Behavior of Working Women: Mediating Effect of Supporting Resources

Purpose@#The purpose of this study was to understand the parenting stress and health promotion behavior of working women, and to investigate the mediating effect of supporting resources. Supporting resources were set as social support of spouse and community, and institutional support of the organization to which the subject belongs based on previous studies and an ecological system theory. @*Methods@#The participants were composed of 214 female workers residing in 17 cities and provinces nationwide and having at least one child aged 1~12 years old. Data were collected online from February 19 to February 28, 2021. The collected data were analyzed using the SPSS 20.0 program to understand the level and correlation of the general characteristics and major variables, and to test the mediating effect, after controlling the variables significantly from univariate analysis, step regression analysis was performed. @*Results@#Among the supporting resources, the mediating effect of social support of spouse and community was statistically significant. @*Conclusion@#These findings suggest that it is necessary to seek ways to increase the social support of working women's spouses and people around them in order to increase the health promotion behavior of working women.

Comparison of Requirement and Activity of Workers' Health Promotion according to Business Type and Enterprise Size / 산업간호학회지

PURPOSE: The purpose of this study was to examine the differences in requirement and activity related to workers' health promotion according to business type and enterprise size. METHODS: This study is a secondary analysis of data extracted from a survey on the Enterprise Health Promotion Index. For the present analysis, 7,784 companies were selected. RESULTS: Requirements for lifestyle management and activities to prevent musculoskeletal disorders were the highest. The requirement and activity of musculoskeletal disorders and cerebrovascular disease were high in the manufacturing industry. Meanwhile, in the non-manufacturing industry, the requirement and activity of job stress management were high. Small-sized companies had a high requirement to prevent musculoskeletal disorders and cerebrovascular disease. CONCLUSION: Government support should be strengthened in workers' lifestyle management. Additionally, workers' health promotion in small-sized companies needs to focus on preventing musculoskeletal disorders and cerebrovascular disease.

Comparison of Requirement and Activity of Workers' Health Promotion according to Business Type and Enterprise Size / 한국직업건강간호학회지

PURPOSE@#The purpose of this study was to examine the differences in requirement and activity related to workers' health promotion according to business type and enterprise size.@*METHODS@#This study is a secondary analysis of data extracted from a survey on the Enterprise Health Promotion Index. For the present analysis, 7,784 companies were selected.@*RESULTS@#Requirements for lifestyle management and activities to prevent musculoskeletal disorders were the highest. The requirement and activity of musculoskeletal disorders and cerebrovascular disease were high in the manufacturing industry. Meanwhile, in the non-manufacturing industry, the requirement and activity of job stress management were high. Small-sized companies had a high requirement to prevent musculoskeletal disorders and cerebrovascular disease.@*CONCLUSION@#Government support should be strengthened in workers' lifestyle management. Additionally, workers' health promotion in small-sized companies needs to focus on preventing musculoskeletal disorders and cerebrovascular disease.

Evaluation on Criterion Validity of Enterprise Health Promotion Index / 한국직업건강간호학회지

PURPOSE: This study was conducted to evaluate the validity of the ‘ Enterprise Health Promotion Index’, a tool for assessing health promotion activities of worksite developed by the Ministry of Employment and Labor and the Korea Occupational Safety and Health Agency. METHODS: This is designed a methodological study that evaluates the validity of the Enterprise Health Promotion Index. For this study, a questionnaire survey was conducted for the workplace health professional and safety professional, and a total of 297 data were extracted as final data. We developed the informal health promotion needs and activity measurement tools. The correlation coefficient between the score of the enterprise health promotion index and the score of the informal health promotion tool was analyzed for the criterion validity evaluation. RESULTS: The criterion validity of the Enterprise Health Promotion Index and activity index were supported by finding moderate (r=.597) and high (r=.783) correlation coefficient. However, the requirement index has low levels of criterion validity (r=.364). CONCLUSION: Based on these results, we suggest to improve the utility of the corporate health promotion index by developing user manual, active public relations, and providing briefing sessions.

Grounded Theoretical Analysis on the Hospital Accreditation Experience of Head Nurses in General Hospitals / 간호행정학회지

PURPOSE: The purpose of this study was to conduct a grounded theoretical analysis on the hospital accreditation experience of head nurses in order to understand their behavior on the adaption of this new system. METHODS: The participants were 8 head nurses with more than 3 years of experience. The data were collected through in-depth interviews using audiotape recording analyzed by the constant comparative method described in Strauss and Corbin's methodology. RESULTS: There were 113 concepts, 26 subcategories and 12 categories identified through the open coding process. In the axial coding, the following paradigm model was proposed: 1) the causal conditions were ‘hardware problem’ and ‘software problem’, 2) the contextual conditions were ‘vertical relationship’, ‘individual preference’, and ‘family support’, 3) the intervening conditions were ‘passive conditions’ and ‘active conditions’, 4) the action/interaction strategies were ‘leading role’ and ‘dependent role’, 5) the consequences were ‘positive acceptance’ and ‘negative acceptance’, 6) the central phenomenon was ‘difficult situation’ and 7) the core category was ‘leading in harmony’. CONCLUSION: The new system led head nurses having difficulties as the middleman between the hospital administration and general nurses, but they made a continuous effort to overcome and adapt to it through a number of strategies.

Job Stress and Mental Health of Female Household Head Workers / 한국직업건강간호학회지

PURPOSE: The purpose of this study is to identify job stress and psychological health of female household head workers and investigate the relationship between them. METHODS: This study was cross-sectionally designed. We analysed the secondary data extracted from the 2nd and 3rd Korean Working Condition Survey. 4,807 female employees were included in the final analysis. χ² test and multiple logistic regression using IBM SPSS 23.0 were performed. RESULTS: 46.7% of female household head workers were in poor psychological health. In the area of job stress-related characteristics affecting the level of psychological health, it was found that female household head workers had a higher likelihood of becoming psychologically unhealthy due to organizational relationships and inadequate compensation factors. CONCLUSION: Considering the fact that the number of female household head workers is gradually expanding as a breadwinner, it is necessary to find a way of paying attention to their job stress and psychological health in order to support them.

Physical and Psychosocial Risk Factors Affecting Mental Health and Presenteeism among South Korean Hairdressers / 한국직업건강간호학회지

PURPOSE: The purpose of this study was to examine the relationship among physical and psychosocial risk factors, mental health, and presenteeism of South Korean hairdressers. METHODS: This study is a secondary analysis of data extracted from the 2014 Korean Working Conditions Survey (KWCS), conducted by the Korea Occupational Safety and Health Agency. For the present analysis, 920 hairdressers were selected. Based on existing literature, a set of variables was chosen from the KWCS. A multiple logistic regression analysis was performed to examine the association among risk factors in working place, mental health, and presenteeism. RESULTS: The prevalence of poor mental health and presenteeism was 45.1% and 36.0%, respectively. The results of multiple logistic regression analysis indicated that ‘repetitive hand or arm movements,’ were significant predictors of mental health (OR: 0.63, CI: 0.41~0.97), and ‘role clarity’ was a significant predictor of presenteeism (OR: 1.86, CI: 1.10~3.13). CONCLUSION: Based on these results, we suggest to improve the clarification of the role of hairdressers as a strategy to reduce their presenteeism.

Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease

The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P=0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.

Single-port access versus conventional multi-port access total laparoscopic hysterectomy for very large uterus

OBJECTIVE: The aim of this study was to compare the surgical outcomes of single-port access (SPA) and conventional multi-port access total laparoscopic hysterectomies (TLH) among patients with very large uteri (500 g or more). METHODS: Fifty consecutive patients who received TLH for large uterine myomas and/or adenomyoses weighing 500 g or more between February 2009 and December 2012 were retrospectively reviewed. SPA and conventional TLH were each performed in 25 patients. Surgical outcomes, including operation time, estimated blood loss, postoperative hemoglobin change, postoperative hospital stay, postoperative pain, and perioperative complications, were compared between the two groups. RESULTS: There were no significant demographic differences between the two groups. All operations were completed laparoscopically with no conversion to laparotomy. Total operation time, uterus weight, estimated blood loss, and postoperative hemoglobin change did not significantly differ between the two groups. Postoperative hospital stay was significantly shorter for the SPA-TLH group compared to that of the conventional TLH group (median [range], 3 [2.0-6.0] vs. 4 [3-7] days; P=0.004]. There were no inter-group differences in postoperative pain at 6, 24, and 72 hours after surgery. There was only one complicated case in each group. CONCLUSION: SPA-TLH in patients with large uteri weighing 500 g or more is as feasible as conventional TLH. SPA-TLH is associated with shorter hospital stays compared to that of conventional TLH.

Factors Affecting Suicidal Ideation of the Low-income Elderly Living Alone

PURPOSE: The purpose of this research is to identify factors affecting suicidal ideation of the low-income elderly. METHODS: The study subjects were lowest-income(basic living allowance) and lower-income elders who were registered for home visiting services at five District Health Centers in Seoul. Interview data were collected from 280 elders and analyzed. Using SPSS/WIN 21, chi2-test and t-test were conducted to analyze the relationship between the subjects' characteristics and their suicidal ideation, and logistic regression was done to identify factors affecting suicidal ideation. RESULTS: Of the subjects, 48.6% had suicidal ideation for the last one year. Self-evaluated psychological status, quality of sleep, depression, and loneliness were affecting factors to the subjects' suicidal ideation. CONCLUSION: Psychological and social factors are strongly related to the suicidal ideation of the elderly who are living alone in metropolitan areas. Therefore, home visiting services should supply physical, psychological and social cares continuously to the low-income elderly, especially those who live alone in metropolitan areas.

Cancer cell metabolism: implications for therapeutic targets

Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor suppressors, thereby fundamentally advancing cancer progression. In this respect, inhibition of glycolytic capacity may contribute to an anticancer effect on malignant cells. Understanding the mechanisms of aerobic glycolysis may present a new basis for cancer treatment. Accordingly, interrupting lactate fermentation and/or other cancer-promoting metabolic sites may provide a promising strategy to halt tumor development. In this review, we will discuss dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as hexokinase, phosphofructokinase, pyruvate kinase M2, lactate dehydrogenase, pyruvate dehydrogenase kinase and glutaminase. The proper intervention of these metabolic sites may provide a therapeutic advantage that can help overcome resistance to chemotherapy or radiotherapy.

Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is thought to account for more than 80% of primary liver cancers. Both HBV and HCV can establish chronic liver inflammatory infections, altering hepatocyte and liver physiology with potential liver disease progression and HCC development. Cyclophilin A (CypA) has been identified as an essential host factor for the HCV replication by physically interacting with the HCV non structural protein NS5A that in turn interacts with RNA-dependent RNA polymerase NS5B. CypA, a cytosolic binding protein of the immunosuppressive drug cyclosporine A, is overexpressed in many cancer types and often associated with malignant transformation. Therefore, CypA can be a good target for molecular cancer therapy. Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection. This review describes CypA inhibitors as a potential HCC treatment tool that is contrived by their obstructing chronic HCV infection and summarizes roles of CypA in cancer development.

Effects of a Health Education Program based on Social Cognitive Theory on the Health Promotion of University Students with Metabolic Syndrome

PURPOSE: The purpose of this study is to evaluate effects of a health education program based on social cognitive theory on university students with risk factors for metabolic syndrome. METHODS: A nonequivalent control group pretest-posttest design was used. Participants were 88 students who had at least 2 risk factors for Metabolic Syndrome (47 students for the experimental and 41 for the control group). The health education program consisted of thirteen sessions. Knowledge regarding smoking and alcohol drinking, self-efficacy and self-esteem were evaluated. t-test, chi2-test, Fisher's exact test, and paired t-test were conducted to analyze the data. SPSS/WIN 19.0 Statistics program was used. RESULTS: There was a statistically significant increase in self-efficacy in the experimental group compared to the control group. No significant changes in knowledge and self-esteem were found. CONCLUSION: The results suggest that the health education program for university students was partially effective. Further work is required to develop more effective health education programs.

Factors that Have Effects on Public Health Center Volunteers' Satisfaction with Their Work

PURPOSE: This study was to investigate the relationship between self-esteem and satisfaction with volunteer work in a population of health care center volunteers. Ultimately, the results from this study would help to find ways to keep volunteers continuing their work. METHODS: The participants of this study were 179 volunteers who were affiliated with three health care centers located in Gyeonggi-do. Descriptive statistics and multi-stage regression were conducted to analyze data. RESULTS: Self-esteem was significantly associated with the satisfaction with volunteer activity. In addition, the relationship with clients rather than volunteers' general characteristics was also significantly related to the satisfaction with volunteer work. CONCLUSION: Therefore, it is necessary to increase a volunteer's self-esteem so that the volunteer can keep continuing his or her volunteering activities. Also, in order to promote good relationships between the volunteers and the clients, it will be important to teach communication skills to volunteers.

The function of p27(KIP1) during tumor development

Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which ensure the correct timing of CDK activation in different phases of the cell cycle. One CKI of importance is p27(KIP1). The regulation and cellular localization of p27(KIP1) can result in biologically contradicting roles when found in the nucleus or cytoplasm of both normal and tumor cells. The p27(KIP1) protein is mainly regulated by proteasomal degradation and its downregulation is often correlated with poor prognosis in several types of human cancers. The protein can also be functionally inactivated by cytoplasmic localization or by phosphorylation. The p27(KIP1) protein is an unconventional tumor suppressor because mutation of its gene is extremely rare in tumors, implying the normal function of the protein is deranged during tumor development. While the tumor suppressor function is mediated by p27(KIP1)'s inhibitory interactions with the cyclin/CDK complexes, its oncogenic function is cyclin/CDK independent, and in many cases correlates with cytoplasmic localization. Here we review the basic features and novel aspects of the p27(KIP1) protein, which displays genetically separable tumor suppressing and oncogenic functions.